منابع مشابه
Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood.
Refractory cytopenia of childhood is the most common subtype of myelodysplastic syndrome in children. In this study, we compared the outcome of immunosuppressive therapy using horse antithymocyte globulin (n=46) with that using rabbit antithymocyte globulin (n=49) in 95 patients with refractory cytopenia of childhood and hypocellular bone marrow. The response rate at 6 months was 74% for horse ...
متن کاملBone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood.
Refractory cytopenia of childhood is the most common type of childhood myelodysplastic syndrome. Because the majority of children with refractory cytopenia have a normal karyotype and a hypocellular bone marrow, differentiating refractory cytopenia from the immune-mediated bone marrow failure syndrome (very) severe aplastic anemia can be challenging. Flow cytometric immunophenotyping of bone ma...
متن کاملClinical Relevance of p53 Immunohistochemical Stain in the Differential Diagnosis Between Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood
Dear Editor, Refractory cytopenia of childhood (RCC) is the most common subtype of hypoplastic myelodysplastic syndrome (hMDS) in childhood, characterized by persistent cytopenia, dysplastic changes in erythroid precursors or megakaryocytes, and the presence of erythroid islands, defined as more than 10 erythroid precursors in a bone marrow (BM) biopsy section [1, 2]. Since 75% of the patients ...
متن کاملHaematopoetic stem cell transplantation for refractory autoimmune cytopenia.
This study describes the outcome of patients receiving haematopoietic stem cell transplantation (HSCT) to treat severe refractory autoimmune cytopenia. The registry of the European Group of Blood and Marrow Transplantation holds data on 36 patients receiving 38 transplants, the first transplant was autologous for 27 and allogeneic for nine patients. Patients had autoimmune haemolytic anaemia (a...
متن کاملImmunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia.
It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy consisting of antithymocyte globulin and cyclosporine. At 6 months, 22 of 29 ...
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ژورنال
عنوان ژورنال: Indian Journal of Pathology and Microbiology
سال: 2012
ISSN: 0377-4929
DOI: 10.4103/0377-4929.97916